Jeffery B Klauda
University of Maryland, College Park
Our collaborative EAGER proposal will focus on dimerization of two COVID19 accessory proteins (ORF7a and ORF7b). We expect to obtain details of the pathogenic association of ORF7a and a human receptor protein BST-2 along with understanding how self-association of ORF7b together modulate the host immune system. This will lead to potential discoveries of peptide sequences that could inhibit these protein associations. The focus of this side of the collaboration is using computational tools to investigate the association of these transmembrane proteins.
transmembrane protein helix dimerization computational biology molecular dynamics molecular simulation